Home Details for 322 Historic Route 66 E

Don’t miss this rare opportunity to own a piece of history while creating your future on one of America’s most iconic highways—Historic Route 66! Ideally located in the heart of Waynesville, this landmark commercial property offers exceptional visibility, convenient access, and endless possibilities for entrepreneurs, investors, and business owners seeking a unique opportunity in a thriving area. Positioned along the famous Route 66 corridor with strong traffic exposure, this property benefits from year-round visibility from local residents, travelers, and the steady flow of military traffic from nearby Fort Leonard Wood. With its prime location, ample parking, and flexible layout, this building provides the perfect foundation for various business ventures while also offering built-in income-producing potential. Step inside to discover a front reception area designed to greet clients and customers, along with four spacious private offices that provide plenty of room for a professional workspace, multiple businesses, or a growing company. A conveniently located bathroom completes the main level. The current layout makes this property an excellent fit for attorneys, insurance companies, financial services, boutiques, salons, restaurants, retail concepts, or investors looking to add a valuable commercial asset to their portfolio. The opportunity continues upstairs, where you’ll find two separate apartment spaces, each featuring its own kitchen area and bathroom. These units offer incredible flexibility and can be utilized for short-term rentals, long-term tenants, employee housing, additional office space, or supplemental rental income. Combining commercial operations with residential income creates a unique advantage. Whether you envision restoring its legacy as a professional office, creating a destination business that captures the charm of Historic Route 66, opening a restaurant or retail concept, or maximizing the income potential as an investment property—the possibilities are truly endless. Surrounded by local attractions, community growth, and the constant activity of travelers passing through the area, this property offers the perfect blend of history, location, visibility, and opportunity. Own a piece of Route 66 history and turn your vision into reality! Properties like this don’t come available often—schedule your private showing today and explore the possibilities.

• Utilities

  • Electricity Connected
  • Sewer Connected
  • Water Connected
  • Propane

• Cooling Information

  • Central Air
  • Electric

• Heating Information

  • Forced Air
  • Propane

• Water Features

  • Public

• Parking

  • Additional Parking